Pharmacological and behavioral characterization of the monoaminergic and GABA - ergic systems of Wfs 1 - deficient mice

THE MORPHO-FUNCTIONAL STATE OF THE BRAIN UNDER CONDITIONS OF HYPOKINESIA AND ITS POSSIBLE PHARMACOLOGICAL CORRECTION BY GABA-ERGIC SUBSTANCES

In this paper it has been shown that deterioration of the brain cortex capillary system and negative dynamics of cerebral tissue morphology occur under conditions of hypo kinesia. Simultaneously, gamma-aminobutyric acid (GABA) and piracetam have been shown to favor the development of vasodilation and prevent further worsening of the cerebral blood supply. During the experiment, it was also ...

Hydroethanolic extract of Carthamus tinctorius induces antidepressant-like effects: modulation by dopaminergic and serotonergic systems in tail suspension test in mice

Objective(s): Studies indicate that major deficiency in the levels of monoaminergic transmitters is a reason for severe depression. On the other hand, it is shown that Carthamus tinctorius L. (CT) may improve neuropsychological injuries by regulation of the monoamine transporter action. Hence, the present study was undertaken to evaluate the involvement of monoaminergic systems in antidepressan...

Non-rem Sleep Stage Transitions Control Rem Sleep Rhythm

1423 Stage Transition Mechanism for Ultradian Rhythm—Kishi et al neurons themselves. Although further modifications of the original reciprocal interaction model, e.g., the incorporation of selfinhibitory cholinergic autoreceptors and excitatory interactions between cholinergic and non-cholinergic REM-on neurons, have been proposed over the past 30 years with new findings of synaptic details of ...

Cholecystokinin2 Receptor Deficient Mice: Changes in Function of Gaba-ergic System

O6: Pathophysiology of Anxiety Disorders

The most important risk factors for anxiety disorders include genes, early life stress, and current stress. These factors do not act independently but interact with each other throughout human development through examples such as epigenetic modifications and complex forms of learning. The neural substrate of pathological anxiety includes hyperactivity in the amygdala and other limbic brain regi...